The Bulletín of Kanagawa Dental College.

Vol. 35 No. 2      September 2007

ISSN: 0385-1443      UBIC: 65

Abstract

Mmp2''' mice, lacking a matrix (ECM) degrading enzyme MMP-2, showed decreased bone mineral density in limb and trunk bones, but increased bone volume in calvariae. In the long bones, there was moderate disruption of the osteocytic networks and reduced bone density throughout life, while osteoblast and osteoclast function was normal. In contrast, aged but not young Mmp2''' mice had calvarial sclerosis with cell death of osteocytes. Severe disruption of osteocytic networks preceded osteocyte loss ¡n Mmp2''' calvariae. Local roles of MMP-2 expressed by the bone cells seem to be critical in bone metabolism. Our results indicate that MMP-2 plays a crucial role in formation and maintenance of the osteocytic canalicular network, which controls remodeling and mineralization in reflection of their mechanical environment. Key words: MMP-2, osteocyte, mineralization, bone, abnormality.

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