The Bulletín of Kanagawa Dental College

Vol. 36 No. 2       September- 2008

ISSN: 0385-1443      UBIC: 65

ABSTRACT

Objective: To investigate the influence of diabetes on trabecular structure of the mandible in a spontaneous animal model of diabetes mellitus. Methods: Glucose tolerance testing and monitoring of urine glucose was performed from 8 weeks to 81 weeks of age in Goto-Kakizaki diabetic rats (DM group: n = 10) and Wistar rats (control group: n = 9). Mandibular molar bone was resected and evaluated by pQCT to analyze bone mineral density (BMD), cross-sectional morphology, and the bone strength index. Micro CT was also performed to evaluate the 3-dimensional structure of bone from the same site, including the alveolar crest level, morphometric indices, connectivity index, and continuity index. Results: The alveolar crest level did not significantly differ between the DM and control groups. As compared to the control group, the trabecular BMD was significantly decreased in the DM group, but there was no significant difference in cortical BMD. However, parameters of morphological changes and the SSI, an index of bone strength, were significantly decreased in the DM group vs. the control group. Morphometric indices, the connectivity index, and the continuity index showed a coarser trabecular structure in the DM group vs. the control group. Conclusion: Diabetes has a significant effect on mandibular trabecular structure and may lead to a deterioration in bone quality. Key words: Diabetes / Bone structure / Mandible / Bone morphometry

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