INTERNATIONAL JOURNAL OF ORAL-MEDICAL SCIENCES

Vol. 7 No. 2      December - 2008

ISSN: 1347-9733      UBIC: 136-M

Abstract

A rare case of cavernous lymphangioma of the lower lip in a 9-year- old girl is reported with clinicopathological, histopathological, and immunohistochemical analyses. Of the benign soft tissue tumors (610 cases) treated at Nihon University School of Dentistry at Matsudo over the past 12 years, angiomas have accounted for about one-third (33.9%), including fine cases of lymphangioma and 198 cases of hemangioma, for a 1: 23 ratio. Lymphangioma is composed of diffusely arranged lymph vessels lined by a single layer of endothelial cells. On immunostaining with D2-40, endothelial cells of lymph vessels showed positivity, but those of blood vessels were negative. The Ki-67 labeling index (LI) was lower for endothelial cells of lymph vessels (LI: 2.0) than for blood vessels in cavernous hemangioma (LI: 4.0). These results indicate that D2-40 is useful for discriminating between lymphatic vessels and blood vessels, and that cavernous lymphangioma is a hamartoma. Keywords: cavernous lymphangioma, lower lip, D2-40, Ki-67

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