JAPANESE JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

Vol. 54 No. 3       2008

ISSN: 0021-5163      UBIC: 151-J

ABSTRACT

A 68-year-old woman with buccal carcinoma had consciousness disorder, appendicular ankylosis, and spasm just after chemotherapy with cisplatin (CDDP) and 5-FU. Brain CT and MRT showed no abnormalities. On laboratory studies, the serum sodium was 106 mEq/1 and the urine sodium 160 mEq/l. Osmolalities of plasma and urine were 238 and 603 mOsm/kgH2O, respectively. Syndrome of inappropriate secretion of antidiuretic hormone (SL'\DH) secondary to chemotherapy with CDDP was diagnosed. To avoid central pontine myelinolysis (CPM) due to the rapid rise in the serum sodium concentration, we provided adequate fluid supplementation according to her urine volume and hypertonic saline transfusion. Four days after starting hypertonic saline transfusion, the serum sodium concentration rose to 135 mEq/l and her symptoms almost disappeared. Serum sodium should be measured frequently for the early detection and treatment of SIADH during and after chemotherapy with CDI)P. Key words: oral cancer, chemotherapy, CDDP, SIADH

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